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Methods: The effect of either hydrophilic intestine restricted fernesiod X receptor (FXR) antagonist Glycine-beta-Muricholic acid (Gly-b-MCA) or hydrophilic Ursodeoxycholic acid (UDCA) treatment at a dose of 160mg/kg/day for 4 weeks on bile acid pool and composition, hepatic inflammation, ductular reaction, and portal fibrosis were investigated in Cyp2c70 KO mice