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In addition, transient receptor potential mucolipin 1 (TRPML1), a non-selective cation channel localized on lysosomal membranes, participates in maintaining iron balance through regulation of lysosomal exocytosis (177)

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Lysosomal dysfunction might play an important role in the development of various diseases, including tumors 14,15,16 , neurodegenerative diseases 17,18,19 , inflammatory diseases 20,21,22 , and cardiovascular diseases 23,24,25 (Table 1)