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The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5±kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

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8 weeks: ~3 vials 12 weeks: ~6 vials 16 weeks: ~8 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks: ~56 syringes 12 weeks: ~84 syringes 16 weeks: ~112 syringes Bacteriostatic Water (30 mL bottle) Use 3.0 mL per 12 mg vial for reconstitution