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Glutathione synthesis is highly compartment specific (e.g., localized in chloroplasts and the cytosol in Arabidopsis ) but it can be found in different concentrations within the different organelles and accumulates in certain organelles during environmental stress conditions as discussed below

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However, using highly-charged peptides like lysine (K) and glutamic acid (E) may confer undesirable properties, including aggregation and immune responses which remain to be full elucidated