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While ERRs are structurally related to estrogen, they don’t need estrogen for activation, and they instead regulate distinct metabolic pathways.2 As such, researchers study SLUPP332 in the following areas: • Estrogen-related receptor pharmacology • Nuclear receptor signaling • Gene transcription • Mitochondrial biogenesis • Oxidative phosphorylation • Cellular energy metabolism • Skeletal muscle cell biology • Structure-activity relationship studies • Small-molecule agonist development Estrogen-Related Receptor Activation – SLU PP 332 is a pan-agonist of ERRs, meaning it activates all three receptor subtypes (ERRα, ERRβ, and ERRγ)

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