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Methodical assessment models deployed for NAD+ versus copper-peptide complexes like GHK-Cu systematically strip away anecdotal bias, focusing on its high affinity for copper ions (Cu2+) and extracellular matrix remodeling capabilities that stimulate collagen, elastin, and glycosaminoglycan synthesis, while rigorously documenting localized dermatological side effects, temporary skin redness, or mild hypersensitivity reactions during topical or systemic application trials