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Neoseptins, small molecules with no relationship to the structure of LPS, were shown to bind to the TLR4-MD2 complex in such a manner that two drug molecules trigger a conformational change similar to that elicited by an authentic LPS molecule

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This molecule is unusually resistant against autooxidation by molecular oxygen, documented also by its thiol-disulfide couple standard redox potential, being − 0.06 V