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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models

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Screen potential drugs for clinical translation The existence of the E-P-OS network makes simultaneously improving hormonal imbalance and OS status a highly promising therapeutic strategy for treating uterine fibroids