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[] It is not surprise that the upstream positive (e.g., SIRT1, [] Akt, [] and c-jun [] ) and negative regulators (e.g., carnitine palmitoyltransferase 1A, [] stearoyl CoA desaturase 1, [] Smo, [] tristetraprolin, [,] and small ubiquitin-related modifier [SUMO]-specific protease 2 [] ) of hepatic FGF21 are involved in the adipose homeostasis, these hepatic genes transit signals to the adipose through modulating hepatic FGF21 expression, secretion, and stabilization

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This ensures consistent uniformity, high glutathione loading, and targeted delivery