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Indeed, alpha-tocopherol has been shown to inhibit ferroptosis by reducing reactive oxygen species (ROS) accumulation, iron overload, lipid peroxidation, and mitochondrial dysfunction, thereby promoting neural function recovery in rats with SCI through the downregulation of ALOX15 (Zhu et al., 2024)

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Second, tumor heterogeneity, manifested as intertumoral variability in death pathway activation (e.g., SLC7A11 expression gradients influencing disulfidptosis susceptibility between primary and metastatic lesions)