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congenital heart disease-associated PAH is the most common form in China, whereas infectious causes such as schistosomiasis is common in countries such as Brazil PAH registries worldwide continue to report improvement in survival with the use of current PAH therapy Five classes of drugs are now approved for the treatment of PAH, including endothelin 1 receptor antagonists, phosphodiesterase type 5 inhibitors, soluble guanylate cyclase stimulators, prostacyclin analogues, and prostacyclin IP receptor agonist Combination therapy is currently considered standard of care in PAH, and evidence supports the early and aggressive use of combination therapy at the time of diagnosis Abstract In the past 2 decades, major changes have occurred in the epidemiological and treatment landscape of pulmonary arterial hypertension (PAH)

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