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a linear epitope typically includes at least 3 or at least 4, and more usually, at least 5 or at least 6 or at least 7, for example, about 8 to about 10 amino acids in a unique sequence

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ABCB4 mutations in the adult population can present with intrahepatic cholelithiasis, PFIC3, ICP, or low phospholipid-associated cholestasis (LPAC) syndrome (Table 1)