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Interestingly, in mGluR1/5, the binding of the agonist to one of the subunits was necessary for receptor activation (137), while the activation of mGluR1 homodimer required the binding of the ligand to both subunits (137)

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This confirms that both have better reconstitution capacity upon secondary transplantations and indicates that Mda5 -/- HSCs show diminished differentiation, potentially due to their more quiescent nature