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Biological effects of growth factors: platelet-derived growth factor Platelet-derived growth factor is a member of a multifunctional polypeptide family that binds to two cell membrane tyrosine kinase receptors (platelet-derived growth factor-Rα and platelet-derived growth factor-Rβ) and subsequently exerts its biological effects on cell proliferation, migration, extracellular matrix synthesis, and anti-apoptosis (54, 69, 134, 144)
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In this period, since the syncytiotrophoblast cells do not express the antioxidant mitochondrial superoxide dismutase (SOD), ROS levels are high, inducing the production of factors that regulate cell proliferation and angiogenesis, such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), which are abundantly expressed in the placenta [20]
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