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This Nrf2-induced enzymatic machinery includes enzymes mediating glutathione (GSH) synthesis, the thioredoxin (Trx) enzyme system and detoxifying enzymes like heme oxygenases (HO), or NAD(P)H: quinone oxidoreductase 1 (NQO1)

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However, the efficacy of the thymus diminishes over time, which may lead to tissue damage and diminished immunity