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Furthermore, nuclei of dystrophic glia cells and neurons were found to contain oxidized DNA (Haider et al., 2011), and oxidative injury was associated with inflammation and oxidative burst in activated microglia and macrophages expressing p22phox, an essential subunit of NADPH oxidases (Fischer et al., 2012, Fischer et al., 2013)

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Guanidinoacetate is methylated by SAM to form creatine, producing SAH in the process