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The first approach involves mAbs, such as cetuximab (Erbitux ® —a chimeric anti-EGFR antibody), panitumumab (Vectibix—a fully humanized anti-EGFR antibody), raised against the extracellular domain of EGFR to block ligand binding and receptor activation, and trastuzumab (Herceptin ® ), a recombinant humanized mAb also targeted against the extracellular domain of HER2