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Subsequently, Fe 3+ is reduced to Fe 2+ in cells via the six-transmembrane epithelial antigen of prostaglandin 3 (STEAP3), which is then released into the cytoplasmic unstable iron pool via divalent metal transporter protein 1 (DMT1) or zinc-iron regulatory protein family 8/14 (ZIP8/14) or stored as ferritin (Frazer and Anderson, 2014)