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Because of the loss of protective features and the damage they cause, chronic and neuropathic pain are viewed as “disease states” ( Although they often coexist and complicate each other’s outcome, the exact relation between chronic pain and depression has yet to be elucidated (Sheng et al., 2017)

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Converging evidence from molecular, neuroimaging, and neurophysiological studies shows chronic low-grade neuroinflammation, maladaptive central sensitization, and dysregulated neurotransmission as pathophysiological substrates

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