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2 Phytochemicals for brain health: promise and challenges 2.1 Major neuroprotective phytochemicals 2.1.1 Curcumin Curcumin, a hydrophobic polyphenol isolated from the rhizomes of Curcuma longa , has attracted considerable interest as a candidate therapeutic agent for NDD including PD, AD, HD, MS, ALS, and prion-associated disorders