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Like chloroacetamide GPX4 inhibitors, ML210 results in the accumulation of cellular lipid hydroperoxides whose lethal effects can be prevented by co-treatment with ferrostatin-1 (fer-1) (Figure 1D), a lipophilic radical-trapping antioxidant that specifically rescues cellular effects caused by the loss of GPX4 activity 10–12

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Role for cystathionine gamma lyase (CSE) in an ethanol (E)-induced lesion in fetal brain GSH homeostasis

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