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The toxicity may be enhanced, perhaps synergistically, by oxidative stress and by Michael adduction between aminoacrylate and susceptible nucleophiles such as GS − and protein sulfhydryls and/or by modification of coenzyme in susceptible PLP enzymes

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Assessment of vitamin A status in cause beta-carotene supplements do not pro- chronic obstructive pulmonary disease patients duce vitamin A toxicity, in many cases they and healthy smokers