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Glutamate, another major excitatory neurotransmitter, plays a dominant role in fast neurotransmission in human central nervous system

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The 2023 Journal of Pharmaceutical Sciences paper notes that, "lacking buffering reagents, bWFI has very low ionic strength, no buffering capacity and is prone to sample contamination," which is also why it reports noisy pH-meter signals, and why the USP monograph recommends adding potassium chloride to raise ionic strength before measuring at all