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This demonstrates the reversible pathway between testosterone and 4-androstenedione via 17β-hydroxysteroid dehydrogenase activity, in preference to 5α-reduction, resulting in decreased yields of the physiologically active metabolite DHT, relevant to wound healing

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However, iron and its deregulated homeostasis have been proposed to have a role in the pathogenesis of PD because of its pro-oxidants characteristics that may lead to ROS generation via Fenton and Haber–Weiss reactions (Stohs and Bagchi, 1995