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DEM exposure resulted in a clear accumulation of Keap1-GFP in cytoplasmic autophagosomal foci, an accumulation of Nrf2-GFP in the nucleus and an accumulation of Srxn1-GFP in the cytoplasm, which is in agreement with the current qualitative understanding of the Nrf2 pathway

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Also, we note that in the FY 2026 IPPS/LTCH PPS final rule, we adopted a corresponding update for the SAFER Guides measure under the Medicare Promoting Interoperability Program for eligible hospitals and CAHs (90 FR 37049 through 37051)