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It is suggested that superior activity of PG-TXL may be due to continuous release of paclitaxel.[] In a double blind placebo-controlled study, administration of GA prevented the vincristine-induced neurotoxicity, a well-known principal limiting side effect.[] The loss of tendo-Achilles reflex as an objective parameter of vincristine-induced neurotoxicity was reported to be significantly higher in placebo group as compared to GA group

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10.1007/s00018-012-1070-x 211 TanX.WenY.HanZ.SuX.PengJ.ChenF.et al (2023)