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Iron dyshomeostasis in glial cells—even in the absence of cell death—contributes to the vicious cycle: iron-loaded microglia directly secrete IL-1β and IL-18 to fuel neuroinflammation (Ryan et al., 2023), while reactive astrocytes release hepcidin and pro-inflammatory cytokines, which elevate neuronal iron load and sensitize neurons to ferroptosis (Xiong et al., 2016

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The process involves inserting a needle through the vial's rubber stopper and slowly adding bacteriostatic water to the lyophilized peptide

and is a flavin