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Mutation of the PWWP domain inhibits its DNA methyltransferase activity on nucleosomal substrates in vitro [47] and leads to reduced affinity of Dnmt3a/b for nucleosomes [48]

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Thiazolidinedione (TZD) compounds, such as rosiglitazone (ROSI), pioglitazone (PIO), and troglitazone (TRO), reduced the mortality of mice after GPX4 was loss by inhibiting the action of ACSL4, indicating that these compounds may show potential therapeutic effects on AKI [43, 48]