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Peptides with long half-lives, such as Semaglutide and Retatrutide, produce smooth, sustained exposure that is favored for weekly-dosing pharmacokinetic and metabolic studies

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After 5 days of AngII infusion, when injury-induced phenotypic switching was initiated, 1.6- and 1.5-fold increases in phospho-LRP1 and phospho–PDGFR-β, respectively, were observed in Tβ4 –/Y compared with Tβ4 +/Y VSMCs (Figure 7B)