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Individuals who have deletions of the entire NF1 gene have an increased risk of facial dysmorphism, mental retardation, early appearance of neurofibromas, and the presence of plexiform neurofibromas.1 In addition, individuals who have a specific 3 base pair in-frame deletion in exon 17 of the NF1 gene may have café-au-lait spots, intertriginous freckling and Lisch nodules, but do not develop cutaneous, subcutaneous or plexiform neurofibromas

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• Type IV (Cell-Mediated Reactions): As they occur after at least 24 hours of exposure to the allergen, type IV allergic reactions are also called the delayed type of hypersensitivity or allergic reactions