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Therefore, obese people with body mass index (BMI) ≥ 40 kg/m 2 have been advised to undergo bariatric surgery [48]

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The absence of efficacy of this targeted agent may reflect the low numbers of β3-adrenoreceptors on human, compared to murine, adipocytes, and the weak effect of β3 activation on lipolysis in human subcutaneous adipose tissue, compared to β1- and β2-adrenoreceptor activation (see Supplementary Information)