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Firstly, the sample size was relatively small, and the findings have not been replicated in an independent, large-scale cohort or external validation cohort

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In this setting, Cys2 is known to increase the activity of betaine-homocysteine methyltransferase-this is the so-called Cys2-sparing effect of Met, which is readily observed when Cys2 is added to a low-Met diet in animal models (20)