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212,213 Stimulating P2X 7 R in neocortical nerve terminals can block the reuptake of GABA and glutamate by the presynaptic membrane and promote the release of these two neurotransmitters in the cerebral cortex of rats and humans, 214,215 and activation of P2X 7 R reduces the expression of GLAST

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For individuals who struggle with excessive hunger or disordered eating patterns, GLP-1 agonists may be more appropriate