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The application of lifting-thrusting and twisting manipulation during acupuncture induces entanglement between the needle shaft and collagen fibers that results in deformation of the connective tissue (Figure 3C)

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Conversely, the glutamate-bound GluK2 K676C/N802C structures represent shallow- and deep- desensitized conformations as well as an intermediate state between these two desensitized states