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Finally, a study in AD patients receiving vitamin B9 (1.2 mg/day) and B12 (50 μg/day) for 6 months reported significant increases in plasma S-adenosylmethionine (SAM) and SAM/SAH ratio, along with reductions in serum homocysteine, plasma SAH, and TNF-α levels, highlighting the therapeutic potential of this approach (209)

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Sodium thiosulfate can also be administered in the out-of-hospital setting