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Compared with commercially available cryopreserved bovine and equine semen, caprine semen exhibits higher levels of cell membrane lipid content, which makes it more susceptible to cryodamage, including ice crystal formation, osmotic stress, and lipid peroxidation during the freezing process [3]

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Clonal HeLa cell lines expressing Cas9 (with a hygromycin selection cassette) or an HRE-GFP ODD reporter construct were previously generated by the laboratory 22