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Immunophenotyping revealed enhanced CD4 + /CD8 + T-cell infiltration (Fig

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While there is little agreement on the actual role these factors play in the pathogenesis of FISS, it is agreed that the events leading to tumor formation in cats following vaccine administration involve the complex interaction of: Intrinsic factors, such as individual genetics and nature and degree of inflammatory response following injection Extrinsic factors, such as type of vaccine administered, frequency of administration, and number of vaccines administered at a site