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Coffee enemas are often used as a supportive tool for encouraging the body's natural detoxification pathways, particularly those involved in liver function. One of the key mechanisms is their ability to increase

Glutathione is an antioxidant, necessary for the neutralizing of reactive oxygen species (or free radicals), as well as the regeneration of other antioxidants such as vitamins C and E [1,2]

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However, HIF-1α activation can inhibit the NF-κB pathway and induce HO-1, thereby attenuating the production of pro-inflammatory cytokines, inhibiting tissue inflammation and decreasing the severity of MIRI