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Different physicochemical options can be used to control sugars and acidity levels, such as the use of cation exchange resins (Lasanta et al., 2012) or electrodialysis with bipolar membranes to increase acidity and therefore reduce pH, or membrane technologies (i.e., reverse osmosis or nanofiltration) to reduce sugar content (El Rayess and Mietton-Peuchot, 2016)

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Overseas suppliers began selling these compounds online, often labeled "for research use only" to sidestep FDA jurisdiction