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NNMT is a cytoplasmic enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

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In obese-mouse and beta-3 adrenergic-receptor knockout models, the lipolytic hGH fragment influenced lipid metabolism in ways consistent with its intended design, and did so without raising IGF-1 — a genuinely interesting preclinical result, but a preclinical one