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CO, on the other hand, increases cyclic guanosine monophosphate (cGMP) generation via soluble guanylate cyclase (sGC) and also exerts its effects on other signalling pathways such as mitogen-activated protein kinase (MAPK) pathways to elicit tissue protection, through anti-apoptotic, anti-inflammatory, anti-proliferative, and pro-angiogenic effects [24]
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