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Drugs associated with cholestatic and mixed cholestatic-hepatocellular injuries, including cyclosporine, ritonavir, rosiglitazone, saquinavir, troglitazone, ketoconazole, pioglitazone, lovastatin, haloperidol, atorvastatin, cerivastatin, bosentan, and chlorpromazine, demonstrated strong inhibition of BSEP activity (66, 67)
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Tamaño:60 cuentas
This action of CHAC1 aligns with its regulation by transcription factors ATF4 and ATF3, suggesting a tightly controlled mechanism whereby CHAC1 contributes to the cellular apoptosis process, particularly in stress responses (Joo et al., 2015)