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doi: 10.1021/ja8059649

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the AnglV analog D ⁇ Nle-Tyr-Ile-NH-(CH 2 ) 5-CONH2 is more metabolically stable than Norleual (Nle-Tyr-Leu ⁇ -(CH 2 -NH 2 f- 4 -His-Pro ⁇ Phe (SEQ ID NO: 1) the AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i ⁇ CHj-NH ⁇ -His-Pro-Phe (SEQ ID NO: 1)) D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats