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2.7.1 Basic science research The three specific sensor proteins of ER stress are activating transcription factor 6 (ATF6), inositol requiring enzyme 1 α (IRE1α), and eukaryotic pancreatic ER kinase (PKR)–like ER kinase (PERK): each one activates subsets of effector genes comprising ATF4, caspase-12, CHOP, bcl, and NF-κB

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