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For example, in rats given subcutaneous KCN (2, 4 and 6 mg/kg), the maximum cyanide blood concentrations reached 51.7, 59.8 and 68.8 μM, respectively

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Oxidation of these enzymes has been reported to lead to a reduction of their activities 33,35,62 , enabling diversion of carbon flux from glycolysis towards nucleotide and glutathione synthesis 62 : Slowing glycolysis down enables for glycolytic intermediates to be pushed towards serine synthesis and consequently folate cycle and/or trans-sulfuration pathway 63 to provide glycine and cysteine, the building blocks for glutathione production (Figs