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Key examples: Diabetes + CKD = diabetic CKD (E11.22) — no explicit “caused by diabetes” statement needed Diabetes + neuropathy = diabetic neuropathy (E11.4x) Diabetes + retinopathy = diabetic retinopathy (E11.3xx) Diabetes + periodontal disease = diabetic periodontal disease (E11.630) However, the provider must not document that the condition is NOT related to diabetes

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This epigenetic regulation is particularly important for maintaining genomic stability and preventing aberrant gene expression during aging