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Research elucidates a novel HMGB1-mediated inflammatory pathway in Non-Alcoholic Fatty Liver Disease (NAFLD), revealing a redox signaling mechanism where ONOO-, formed through NADPH oxidase activation, plays a pivotal role in TLR-4 activation and cytokine release (150)
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Int J Endocrinol 2012(1):561018 [DOI] [PMC free article] [PubMed] [Google Scholar] Van Der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus A-M, Florencia E, Prens EP (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis