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Glutathione is an antioxidant, necessary for the neutralizing of reactive oxygen species (or free radicals), as well as the regeneration of other antioxidants such as vitamins C and E [1,2]

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However, HIF-1α activation can inhibit the NF-κB pathway and induce HO-1, thereby attenuating the production of pro-inflammatory cytokines, inhibiting tissue inflammation and decreasing the severity of MIRI