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Do not freeze reconstituted AOD 9604 Because AOD 9604 contains a critical disulfide bridge between Cys7 and Cys14, freeze-thaw cycles may reduce activity through bridge reduction or scrambling Working dilutions should be prepared fresh for studies where reproducibility matters AOD 9604 Pharmacokinetics AOD 9604 has a plasma half-life of approximately 2 hours following subcutaneous administration in research models