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Collagen Gene Activation & MMP Inhibition GHK-Cu activates genes encoding collagen I, III, and elastin production while simultaneously downregulating matrix metalloproteinases (MMPs) — the enzymes responsible for degrading periodontal ligament fibers in periodontitis

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Activated microglia become a primary source of cytokine production (TNF-α, IL-1β, IL-6), chemokines, nitric oxide, and reactive oxygen species within the brain itself, establishing and perpetuating the state of neuroinflammation (Fakhfouri et al., 2024)